For centuries, people who have sat with mushrooms in ceremony have described something that goes beyond thought alone. They speak of a shift in the body, a felt change that continues after the experience ends. Modern research is now beginning to examine that same possibility. In July 2025, a peer-reviewed study published in npj Aging, part of the Nature portfolio, offered the first experimental evidence that psilocybin may extend cellular lifespan and improve survival in aged mice. A few months later, biohacker Bryan Johnson conducted what is likely the most extensively measured self-experiment ever done around psilocybin, tracking 249 biomarkers across two ceremonial doses. His systemic inflammation dropped by more than 35%, his microbiome changed measurably, and his brain showed greater flexibility and less rumination that lasted beyond the experience. These are very different studies, yet together they suggest that psilocybin may be influencing far more than psychology alone.
Nature study findings
The 2025 npj Aging study found that psilocin, the active metabolite of psilocybin, extended the lifespan of human cells by 29% at a 10 micromolar dose and by 57% at 100 micromolar. Aged mice given psilocybin also showed significantly better survival. Researchers from Baylor College of Medicine and Emory University used a validated model of cellular aging known as replicative senescence, in which human fetal lung fibroblasts are repeatedly divided until they can no longer replicate. Cells exposed to psilocin kept dividing longer than untreated cells, without becoming cancerous. They simply aged more slowly.
In a separate experiment, aged mice treated with psilocybin survived at higher rates than control animals. The researchers suggested psilocybin may act as a “geroprotective agent,” meaning a compound that helps protect against the cellular processes of aging. Their proposed mechanism connects to the psilocybin-telomere hypothesis. Telomeres are the protective caps at the ends of chromosomes, and they shorten as cells divide and as we age. Chronic stress, depression, and anxiety are all linked to telomere shortening. Because psilocybin is known to affect these conditions, it may help protect telomere length and, in turn, cellular aging itself. This was the first experimental test of that hypothesis, and the findings supported it.
Bryan Johnson study findings
While not peer-reviewed, Bryan Johnson’s self-experiment tracked psilocybin with exceptional precision and produced results that align with the cellular research. After two doses separated by a month, he reported benefits across mental, hormonal, metabolic, and anti-inflammatory systems. His systemic inflammation dropped from “elite” levels to undetectable, a decrease of more than 35%. His microbiome showed measurable shifts that he described as dramatic. Brain scans showed reduced activity in the prefrontal cortex and command networks during the experience, along with increased connectivity and cognitive flexibility that continued afterward.
What makes this experiment notable is not that it represents a universal outcome, but that Johnson began from an unusually optimized baseline. Most of his biomarkers were already in the 99th percentile before the experiment started. He was already eating a near-perfect diet, exercising daily, sleeping eight hours a night, and tracking everything he consumed. Even so, psilocybin produced multi-system changes that his other interventions had not. That does not prove anything definitive, but it does suggest psilocybin may reach layers of human biology that diet, exercise, and supplementation alone do not.
Why this matters
This research matters because it suggests psilocybin may be affecting more than mood or perception. It may also be touching the cellular machinery of aging itself. For years, the conversation around psilocybin has centered on consciousness, mystical experience, and reductions in depression scores. Those effects are real and important. But the newer data points to a parallel story unfolding in cells, mitochondria, inflammatory pathways, and the microbiome. Many people who have sat with this medicine have long felt that the body changes after ceremony, even if they had no scientific language for it. Something settles. Something that was running too hot begins to cool. That possibility is now starting to become measurable.
The container
If psilocybin is influencing cellular aging, inflammation, and microbial balance, then the conditions around ceremony matter even more. A medicine doing this much biological work deserves a body that has been prepared to receive it. Sleep, nutrition, hydration, and reduced stress in the weeks beforehand are not just supportive habits; they help create the physiological conditions in which the medicine can land well. At Ananda Lodge, preparation protocols begin weeks before guests arrive. This is not about following rules. It is about creating the best possible conditions for the work to unfold.
If curiosity is pulling at you
Many people who come to Ananda for their first psilocybin retreat have been considering it for some time. They have read, watched, listened, and felt something quietly drawing them closer. The conversation around psilocybin and longevity may make that pull even stronger. We hold psilocybin retreats throughout the year at Ananda Lodge in small groups of up to 10 guests, with deep preparation, somatic support, and three months of integration designed to help the experience translate into lasting change. The retreat is not only the medicine itself, but the container around it. And that container is what helps make the difference between something powerful and something that endures.
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Sun, Nov 8 – Fri, Nov 13